Her experience, while not the norm, is far from unusual, experts say.
Applegate disclosed the revelation on an episode of her podcast with Jamie Lynn Sigler, MeSsy, which centers on their lives with MS. (Sigler disclosed that she has relapsing-remitting multiple sclerosis, or RRMS, in 2016.) “In January of 2021, I had numbness in my toes, and that numbness grew to all of my legs,” Applegate recalled on the podcast. “And then the pain started.”
Not that reliably stops it for all patients or for unlimited time, but the current mainstream treatments are way more effective than what was generally available 15-20 years ago. I’ve been on my current twice-annual infusion for more than 8 years now with no relapses or new lesions. That is a halted disease progression, and though it may not last indefinitely, for the time being, for me, it is effectively stopped, and the same is true for countless others.